(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

Base Information

Chemical Name:(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid
CAS No.:1276021-03-4
Molecular Formula:C₁₉H₁₅F₆NO₃
Molecular Weight:419.323
Hs Code.:

Synonyms:(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

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Chemical Property of (S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

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Technology Process of (S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

There total 3 articles about (S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1370416-19-5
(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid methyl ester

: 1276021-03-4
(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

Guidance literature:: (S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid methyl ester; With sodium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1276021-03-4
(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 1 h / 20 °C

2.2: pH 2

With dmap; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 85068-33-3
3,5-bistrifluoromethylphenyl acetic acid

: 1276021-03-4
(S)-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 1 h / 20 °C

2.2: pH 2

With dmap; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2011.10.051