2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline

Base Information

Chemical Name:2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline
CAS No.:1313405-87-6
Molecular Formula:C₁₉H₁₈ClN₃S
Molecular Weight:355.891
Hs Code.:

Synonyms:2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline

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Chemical Property of 2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline

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Technology Process of 2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline

There total 2 articles about 2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2530-10-1
3-Acetyl-2,5-dimethylthiophen

: 73568-26-0
2-chloro-8-methyl-quinoline-3-carbaldehyde

: 1313405-87-6
2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; ethanol

2: hydrazine hydrate / ethanol

With hydrazine hydrate; sodium hydroxide; In ethanol; water;
DOI:10.2174/1573406410666141229101130

Reference yield:

: 73568-26-0
2-chloro-8-methyl-quinoline-3-carbaldehyde

: 1313405-87-6
2-chloro-3-[3-(2,5-dimethylthiophen-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-8-methylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 2 h / 20 °C

2: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; ethanol; water; 1: Claisen Schmidt condensation;
DOI:10.1007/s00044-011-9647-8