6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

Base Information

Chemical Name:6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide
CAS No.:1427064-59-2
Molecular Formula:C₂₀H₁₈FN₃O₃
Molecular Weight:367.38
Hs Code.:

Synonyms:6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

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Chemical Property of 6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

Chemical Property:

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Technology Process of 6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

There total 4 articles about 6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-fluoro-phenyl)-hydrazine hydrochloride

: 1427064-98-9
6-cyclobutoxy-5-furan-2-ylnicotinic acid

: 1427064-59-2
6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1427064-98-9
6-cyclobutoxy-5-furan-2-ylnicotinic acid

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1427064-59-2
6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 29241-62-1
5-bromo-6-chloronicotinic acid

: 1427064-59-2
6-cyclobutoxy-5-furan-2-ylnicotinic acid N′-(4-fluorophenyl)hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C

2: caesium carbonate; palladium diacetate; catacxium A / toluene; water / 5 h / 120 °C / Inert atmosphere

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine / tetrahydrofuran / 20 °C

With palladium diacetate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; potassium hydroxide; catacxium A; In tetrahydrofuran; water; dimethyl sulfoxide; toluene;