2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

Base Information

Chemical Name:2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid
CAS No.:488713-41-3
Molecular Formula:C₂₅H₁₉N₅O₅
Molecular Weight:469.456
Hs Code.:

Synonyms:2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

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Chemical Property of 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

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Technology Process of 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

There total 12 articles about 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 883971-98-0
2-(3'-cyano-5-formyl-6-hydroxy-biphenyl-3-yl)-succinic acid dimethyl ester

: 3,4-diaminobenzamidine monohydrochloride

: 488713-41-3
2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

Guidance literature:: With oxygen; In ethanol;
DOI:10.1016/j.bmcl.2005.12.060

Reference yield:

: (E)-2-(4-Methoxy-phenyl)-but-2-enedioic acid dimethyl ester

: 488713-41-3
2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

Guidance literature:: Multi-step reaction with 7 steps

1: H₂; Pd(OH)2 / methanol

2: HBr / Heating

3: SOCl₂

4: magnesium chloride; TEA / acetonitrile

5: N-bromosuccinimide / dimethylformamide

6: 95 percent / Pd(PPh₃)4; Na₂CO₃ / toluene

7: 88 percent / O₂ / ethanol

With palladium dihydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; TEA; hydrogen bromide; hydrogen; oxygen; sodium carbonate; magnesium chloride; In methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; 6: Suzuki reaction;
DOI:10.1016/j.bmcl.2005.12.060

Reference yield:

: 488713-20-8
2-(3-formyl-4-hydroxy-phenyl)-succinic acid dimethyl ester

: 488713-41-3
2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-3'-cyano-6-hydroxy-biphenyl-3-yl]-succinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-bromosuccinimide / dimethylformamide

2: 95 percent / Pd(PPh₃)4; Na₂CO₃ / toluene

3: 88 percent / O₂ / ethanol

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxygen; sodium carbonate; In ethanol; N,N-dimethyl-formamide; toluene; 2: Suzuki reaction;
DOI:10.1016/j.bmcl.2005.12.060