(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

Base Information

Chemical Name:(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile
CAS No.:205441-79-8
Molecular Formula:C₁₉H₃₂N₂O₃Si
Molecular Weight:364.56
Hs Code.:

Synonyms:(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

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Chemical Property of (3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

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Technology Process of (3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

There total 8 articles about (3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 205441-96-9
{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyano-1-[(R)-1-(4-methoxy-benzyloxy)-ethyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 205441-79-8
(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

Guidance literature:: With piperidine;

Reference yield:

: 205441-95-8
(2R,3R)-2-(9-fluorenylmethoxycarbonylamino)-3-(4-methoxyphenyl)methoxybutanol

: 205441-79-8
(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin reagent / CH₂Cl₂ / 0.5 h / 20 °C

2: 103 mg / acetonitrile / 3 h / 80 °C

3: piperidine / dimethylformamide / 1 h / 20 °C

With piperidine; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(03)00379-X

Reference yield:

: (2S,3R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-methoxy-benzyloxy)-butyric acid methyl ester

: 205441-79-8
(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 2.40 g / Zn(BH₄)2 / diethyl ether / 12 h / 20 °C

2: Dess-Martin reagent / CH₂Cl₂ / 0.5 h / 20 °C

3: 103 mg / acetonitrile / 3 h / 80 °C

4: piperidine / dimethylformamide / 1 h / 20 °C

With piperidine; zinc(II) tetrahydroborate; Dess-Martin periodane; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(03)00379-X