4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 1272973-58-6
• Molecular Formula: C₁₃H₂₀N₄O₃
• Molecular Weight: 280.327

Synonyms:4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 459.1±55.0 °C(Predicted)
• Density: 1.246±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(5-hydroxypyrimidin-2-yl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

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Technology Process of 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate (374930-88-8) → 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (1272973-58-6)

Guidance literature:

tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; at -70 - -60 ℃; for 0.25h;

With dihydrogen peroxide; acetic acid; In methanol; water; at -20 ℃; for 18h;

DOI:10.1016/j.bmcl.2013.05.089

Reference yield: 89.0%

4-(5-benzyloxypyrimidin-2-yl)piperazine-1-carbamic acid tert-butyl ester → 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (1272973-58-6)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; at 15 ℃; for 0.5h; under 760.051 Torr;

Reference yield:

tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperazine-1-carboxylate (940284-98-0) → 4-(5-hydroxypyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (1272973-58-6)

Guidance literature:

With sodium peroxoborate tetrahydrate; In tetrahydrofuran; water; at 25 ℃; for 16h;

DOI:10.1021/jm300310c

upstream raw materials:

tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperazine-1-carboxylate

1-piperazinecarboxylic acid 4-(2-pyrimidinyl)-, 1,1-dimethylethyl ester

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

tert-butyl 4-(5-(4-(trifluoromethylsulfinyl)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate

tert-butyl 4-(5-(4-(methylsulfinyl)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate

tert-butyl 4-(5-(4-(2-morpholinoethylthio)benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate

3-{[(2-piperazin-1-ylpyrimidin-5-yl)oxy]methyl}benzonitrile

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