(R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

Base Information

Chemical Name:(R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate
CAS No.:1257443-64-3
Molecular Formula:C₂₀H₂₈BrNO₅
Molecular Weight:442.35
Hs Code.:

Synonyms:(R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

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Chemical Property of (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

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Technology Process of (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

There total 3 articles about (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15026-17-2
succinic acid mono-tert-butyl ester

: 1257446-30-2
(R)-ethyl 3-amino-4-(4-bromophenyl)butanoate hydrochloride

: 1257443-64-3
(R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

Guidance literature:: With triethylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 331763-75-8
(R)-4-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)butanoic acid

: 1257443-64-3
(R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 71 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1257446-29-9
(R)-ethyl 4-(4-bromophenyl)-3-(tert-butoxycarbonylamino)butanoate

: 1257443-64-3
(R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;