(1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

Base Information

Chemical Name:(1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile
CAS No.:1259366-36-3
Molecular Formula:C₂₅H₂₂ClFN₆O₂S
Molecular Weight:525.006
Hs Code.:

Synonyms:(1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

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Chemical Property of (1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

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Technology Process of (1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

There total 7 articles about (1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: cis-(3-cyanohexyl)carbamic acid benzyl ester

: 1259009-31-8
5-chloro-3-(5-fluoro-4-methylsulfonyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

: 1259366-36-3
(1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

Guidance literature:: With 20% palladium hydroxide-activated charcoal; hydrogen; In tetrahydrofuran; for 2.25h;

Reference yield:

: cis-(3-cyanohexyl)carbamic acid benzyl ester

: palladium dihydroxide

: IPr₂NEt

: 1259012-01-5
5-chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

: 1259366-36-3
(1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

Guidance literature:: With nitrogen; In tetrahydrofuran;

Reference yield:

: 1259278-09-5
ethyl (1R,3S)-3-benzyloxycarbonylaminocyclohexane-1-carboxylate

: 1259366-36-3
(1R,3S)-3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide; water / tetrahydrofuran

2: pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate

3: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

4: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran / 2.25 h

With pyridine; 1,3,5-trichloro-2,4,6-triazine; di-tert-butyl dicarbonate; 20% palladium hydroxide-activated charcoal; water; hydrogen; ammonium bicarbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;