N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

Base Information

Chemical Name:N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane
CAS No.:387357-09-7
Molecular Formula:C₂₉H₃₁F₂IN₂O
Molecular Weight:588.479
Hs Code.:

Synonyms:N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

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Chemical Property of N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

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Technology Process of N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

There total 4 articles about N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 387357-08-6
N-[3-(4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

: 387357-09-7
N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

Guidance literature:: With Iodine monochloride; In acetic acid; at 20 ℃; for 3h;
DOI:10.1021/jm0101904

Reference yield:

: 882-06-4
4-nitro-trans-cinnamic acid

: 387357-09-7
N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / H₂ / 10percent Pd/C / methanol / 1 h / 2068.65 Torr

2: 4.75 g / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; triethylamine / dimethylformamide / 48 h / 20 °C

3: 4.38 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 74.5 percent / ICl / acetic acid / 3 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; Iodine monochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; 10percent Pd/C; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm0101904

Reference yield:

: 2393-17-1
3-(4-aminophenyl)propionic acid

: 387357-09-7
N-[3-(3-iodo-4-aminophenyl)propyl]-3α-[bis(4'-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 3 steps

1: 4.75 g / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; triethylamine / dimethylformamide / 48 h / 20 °C

2: 4.38 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 74.5 percent / ICl / acetic acid / 3 h / 20 °C

With lithium aluminium tetrahydride; Iodine monochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm0101904