2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

Base Information

Chemical Name:2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate
CAS No.:74356-70-0
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:

Synonyms:2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

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Chemical Property of 2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

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Technology Process of 2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

There total 8 articles about 2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 74356-71-1
5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane hydrobromide

: 74356-70-0
2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

Guidance literature:: With triethylamine; In chloroform; Ambient temperature;
DOI:10.1021/jm00181a005

Reference yield:

: 792132-20-8
5-(4-methoxyphenyl)-2-methyl-2-azabicyclo<3.2.1>octane

: 74356-70-0
2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / CHCl₃

2: 86 percent / HCl / 18 h / Heating

3: 88 percent / HBr / 0.5 h / 120 °C

4: 85 percent / triethylamine / CHCl₃ / Ambient temperature

With hydrogenchloride; hydrogen bromide; triethylamine; In chloroform;
DOI:10.1021/jm00181a005

Reference yield:

: 74356-65-3
5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane

: 74356-70-0
2-(cyclopropylcarbonyl)-5-(4-hydroxyphenyl)-2-azabicyclo<3.2.1>octane cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate, KOH / various solvent(s) / 4 h / 170 °C

2: 93 percent / CHCl₃

3: 86 percent / HCl / 18 h / Heating

4: 88 percent / HBr / 0.5 h / 120 °C

5: 85 percent / triethylamine / CHCl₃ / Ambient temperature

With hydrogenchloride; potassium hydroxide; hydrogen bromide; hydrazine hydrate; triethylamine; In chloroform;
DOI:10.1021/jm00181a005