4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

Base Information

Chemical Name:4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone
CAS No.:1384438-40-7
Molecular Formula:C₁₈H₂₁N₃O₂
Molecular Weight:311.384
Hs Code.:

Synonyms:4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

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Chemical Property of 4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

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Technology Process of 4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

There total 6 articles about 4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1384438-39-4
4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-benzyloxy-2-methyl-3(2H)-pyridazinone

: 1384438-40-7
4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 1h; under 760.051 Torr;

Reference yield:

: 1384438-98-5
4-(2,6-diethyl-4-methylphenyl)-6-hydroxymethyl-5-(4-methylphenylsulfonyl)-2-methyl-3(2H)pyridazinone

: 1384438-40-7
4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 5 °C

3.1: hydrogenchloride / water; methanol / 1.25 h / 65 °C

3.2: 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C

5.1: dimethyl sulfoxide / 0.5 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 760.05 Torr

With hydrogenchloride; hydrogen; phosphorus tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1384438-38-3
4-(2,6-diethyl-4-methylphenyl)-6-hydroxymethyl-5-benzyloxy-2-methyl-3(2H)-pyridazinone

: 1384438-40-7
4-(2,6-diethyl-4-methylphenyl)-6-cyanomethyl-5-hydroxy-2-methyl-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C

2: dimethyl sulfoxide / 0.5 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 760.05 Torr

With hydrogen; phosphorus tribromide; palladium 10% on activated carbon; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate;