(R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Base Information

Chemical Name:(R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine
CAS No.:1610838-95-3
Molecular Formula:C₂₁H₂₂FNO₂
Molecular Weight:339.41
Hs Code.:

Synonyms:(R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Suppliers and Price of (R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

There total 6 articles about (R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.6%

: 1610838-92-0
2-iodo-4-(4-fluorophenoxy)phenol

: 460747-73-3
(R)-1-(but-3-yn-1-yl)-2-methylpyrrolidine

: 1610838-95-3
(R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Guidance literature:: 2-iodo-4-(4-fluorophenoxy)phenol; (R)-1-(but-3-yn-1-yl)-2-methylpyrrolidine; With copper(l) iodide; palladium diacetate; Tri(p-tolyl)phosphine; In acetonitrile; at 25 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

With diisopropylamine; at 60 ℃; for 16h; Inert atmosphere; Schlenk technique;
DOI:10.1039/c3ra46392c

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1610838-95-3
(R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; tetrabutylammomium bromide; potassium phosphate / N,N-dimethyl-formamide / 22 h / Inert atmosphere; Schlenk technique; Reflux

2.1: hydrogen bromide; acetic acid / 16 h / Inert atmosphere; Schlenk technique; Reflux

3.1: iodine; potassium iodide; methylamine / ethanol; water / 1 h / 0 °C / Inert atmosphere; Schlenk technique

4.1: palladium diacetate; Tri(p-tolyl)phosphine; copper(l) iodide / acetonitrile / 0.17 h / 25 °C / Inert atmosphere; Schlenk technique

4.2: 16 h / 60 °C / Inert atmosphere; Schlenk technique

With potassium phosphate; copper(l) iodide; tetrabutylammomium bromide; hydrogen bromide; iodine; palladium diacetate; acetic acid; Tri(p-tolyl)phosphine; methylamine; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ra46392c

Reference yield:

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(R)-(-)-2-methylpyrrolidine

: 1610838-95-3
(R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 24 h / 50 °C / Inert atmosphere; Schlenk technique

2.1: palladium diacetate; Tri(p-tolyl)phosphine; copper(l) iodide / acetonitrile / 0.17 h / 25 °C / Inert atmosphere; Schlenk technique

2.2: 16 h / 60 °C / Inert atmosphere; Schlenk technique

With copper(l) iodide; palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine; In acetonitrile;
DOI:10.1039/c3ra46392c