4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole

Base Information

• Chemical Name: 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole
• CAS No.: 153434-54-9
• Molecular Formula: C₁₄H₁₃N₃OS
• Molecular Weight: 271.343
• Mol file: 153434-54-9.mol

Synonyms:4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole

Chemical Property of 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole

There total 4 articles about 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(Methylthio)-5-(2-phenylethenyl)imidazole-4-carboxylic acid (153434-57-2) → 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole (153434-54-9)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In benzene; at 50 ℃; for 1h;

DOI:10.1021/jo00079a055

Reference yield:

4,5-Dibromo-1-methyl-2-(methylthio)imidazole (145083-26-7) → 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole (153434-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 81.3 percent / n-BuLi / diethyl ether; hexane / 1.) -78 deg C, 30 min, 2.) r.t., 12 h

2: 100 percent / n-BuLi / tetrahydrofuran; hexane / 1.) r.t., 30 min, 2.) r.t., 12 h

3: 93.5 percent / n-BuLi / diethyl ether; hexane / 1.) -78 deg C, 1 h, 2.) r.t., 12 h

4: 98 percent / diphenyl phosphorazidate, Et₃N / benzene / 1 h / 50 °C

With n-butyllithium; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; benzene;

DOI:10.1021/jo00079a055

Reference yield:

4-Bromo-1-methyl-2-(methylthio)imidazole-5-carboxaldehyde (145083-27-8) → 4-Isocyanato-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole (153434-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / n-BuLi / tetrahydrofuran; hexane / 1.) r.t., 30 min, 2.) r.t., 12 h

2: 93.5 percent / n-BuLi / diethyl ether; hexane / 1.) -78 deg C, 1 h, 2.) r.t., 12 h

3: 98 percent / diphenyl phosphorazidate, Et₃N / benzene / 1 h / 50 °C

With n-butyllithium; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; benzene;

DOI:10.1021/jo00079a055

upstream raw materials:

1-(Methylthio)-5-(2-phenylethenyl)imidazole-4-carboxylic acid

4,5-Dibromo-1-methyl-2-(methylthio)imidazole

4-Bromo-1-methyl-2-(methylthio)imidazole-5-carboxaldehyde

4-Bromo-1-methyl-2-(methylthio)-5-(2-phenylethenyl)imidazole

Downstream raw materials:

1-Methyl-2-(methylthio)-6-phenylimidazo<4,5-b>pyridin-5(4H)-one

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine