3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine

Base Information

Chemical Name:3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine
CAS No.:1187951-72-9
Molecular Formula:C₂₄H₂₁N₃O₃S
Molecular Weight:431.515
Hs Code.:

Synonyms:3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine

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Chemical Property of 3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine

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Technology Process of 3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine

There total 2 articles about 3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1187951-53-6
6-benzyl-5-(4-methylphenylsulfonamido)pyrazin-2-yl 4-methylbenzenesulfonate

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1187951-72-9
3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine

Guidance literature:: (p-hydroxyphenyl)boronic acid; With potassium hydrogenfluoride; In methanol; water; Saturated solution;

6-benzyl-5-(4-methylphenylsulfonamido)pyrazin-2-yl 4-methylbenzenesulfonate; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In methanol; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1246/bcsj.82.870

Reference yield: 37.1%

: 98-59-9
p-toluenesulfonyl chloride

: 37156-84-6
4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol

: 1187951-72-9
3-benzyl-5-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]pyrazine

Guidance literature:: p-toluenesulfonyl chloride; 4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol; pyridine; dmap; at 0 - 20 ℃; for 2h; Inert atmosphere;

With water; sodium hydroxide; In methanol; at 65 ℃; for 0.5h;

With sodium hydrogencarbonate; In methanol; water; at 20 ℃;