(R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate
• CAS No.: 205647-74-1
• Molecular Formula: C₁₈H₂₇NO₆S
• Molecular Weight: 385.481

Synonyms:(R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate

Chemical Property of (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate

There total 5 articles about (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

tert-butyl (4S)-4-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (108149-63-9,108149-65-1) + p-toluenesulfonyl chloride (98-59-9) → (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate (205647-74-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 25 ℃; for 16h;

Reference yield: 49.0%

→ (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate (205647-74-1)

Guidance literature:

Reference yield:

4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (108149-63-9) + p-toluenesulfonyl chloride (98-59-9) → (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate (205647-74-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1039/c4ob00535j

upstream raw materials:

4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

p-toluenesulfonyl chloride

methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate

2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

Downstream raw materials:

(S)-3-[4-Benzyloxy-3-((R)-2-tert-butoxycarbonylamino-3-hydroxy-propoxy)-phenyl]-2-(benzyloxycarbonyl-methyl-amino)-propionic acid methyl ester

(S)-tert-butyl 2,2-dimethyl-4-[(4-octylphenoxy)methyl]oxazolidine-3-carboxylate

(R)-tert-butyl [1-hydroxy-3-(4-octylphenoxy)propan-2-yl]carbamate

(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

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