(1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

Base Information

Chemical Name:(1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol
CAS No.:479681-33-9
Molecular Formula:C₂₈H₃₇O₄P
Molecular Weight:468.573
Hs Code.:

Synonyms:(1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

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Chemical Property of (1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

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Technology Process of (1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

There total 5 articles about (1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4455-77-0
(methoxymethyl)diphenylphosphine oxide

: 479680-86-9
(1aR,2aS,6aR,7aR)-1a,2a,6,6-tetramethyl-octahydro-1-oxa-cyclopropa[b]naphthalen-2-one

: 479681-33-9
(1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

Guidance literature:: (methoxymethyl)diphenylphosphine oxide; With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 20 ℃;

(1aR,2aS,6aR,7aR)-1a,2a,6,6-tetramethyl-octahydro-1-oxa-cyclopropa[b]naphthalen-2-one; In tetrahydrofuran; at -78 - -50 ℃;
DOI:10.1016/j.tet.2003.10.017

Reference yield: 99.0%

: lithium derivative of α-methoxymethyldiphenylphosphine oxide

: 479680-86-9
(1aR,2aS,6aR,7aR)-1a,2a,6,6-tetramethyl-octahydro-1-oxa-cyclopropa[b]naphthalen-2-one

: 479681-33-9
(1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(02)01891-9

Reference yield:

: 6485-40-1,2244-16-8
(R)-Carvone

: 479681-33-9
(1aR,2aS,6aS,7aR)-7-[(Diphenyl-phosphinoyl)-methoxy-methyl]-3,3,6a,7a-tetramethyl-decahydro-1-oxa-cyclopropa[b]naphthalen-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 0 °C

1.2: 89 percent / tetrahydrofuran

2.1: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -10 °C

2.2: 86 percent / tetrahydrofuran; hexamethylphosphoric acid triamide

3.1: CF₃CO₂H / 48 h / 20 °C

3.2: H₂O₂; NaOH / methanol / 0 °C

3.3: H₂ / 10 percent Pd/C / ethanol; triethylamine

4.1: 99 percent / tetrahydrofuran / -78 °C

With trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4039(02)01891-9