2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

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Chemical Name:2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester
CAS No.:1365172-94-6
Molecular Formula:C₂₅H₂₇F₃N₆O₃
Molecular Weight:516.523
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

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Chemical Property of 2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

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Technology Process of 2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

There total 6 articles about 2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 1243706-25-3
2-chloro-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,7-dihydropurin-6-one

: 1365172-94-6
2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

: 1365172-90-2
2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-7-ylmethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 24h; Inert atmosphere;

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 1243706-45-7
1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,7-dihydropurin-6-one

: 1365172-94-6
2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

: 1365172-90-2
2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-7-ylmethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Inert atmosphere;

Reference yield:

: 142665-13-2
5,6-diamino-3-propyluracil

: 1365172-94-6
2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-9-ylmethyl ester

: 1365172-90-2
2,2-dimethylpropionic acid 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,6-dihydropurin-7-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 6 h / 0 - 25 °C

2: phosphorus pentoxide / N,N-dimethyl-formamide / 0.5 h / 100 °C

3: trichlorophosphate; ammonium chloride / 72 h / 120 - 125 °C

4: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 - 50 °C / Inert atmosphere

With phosphorus pentoxide; potassium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In methanol; N,N-dimethyl-formamide;