[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

Base Information

Chemical Name:[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester
CAS No.:918299-36-2
Molecular Formula:C₂₂H₃₂N₂O₉
Molecular Weight:468.504
Hs Code.:

[3-(2-<i>tert</i>-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

Synonyms:[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

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Chemical Property of [3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

There total 4 articles about [3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223678-03-3
Allyl 3,5-dihydroxybenzoate

: 918299-36-2
[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / potassium carbonate / dimethylformamide / 20 h / Heating

2: 67 percent / piperidine / palladium phosphine / tetrahydrofuran / 2 h / 20 °C

3: 97 percent / iPr₂NEt; HATU / dimethylformamide / 1 h / 20 °C

With piperidine; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium phosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0614159

Reference yield:

: allyl 3,5-bis(ethoxycarbonylmethoxy)benzoate

: 918299-36-2
[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / piperidine / palladium phosphine / tetrahydrofuran / 2 h / 20 °C

2: 97 percent / iPr₂NEt; HATU / dimethylformamide / 1 h / 20 °C

With piperidine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium phosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0614159

Reference yield:

: 99-10-5
3,5-Dihydroxybenzoic acid

: 918299-36-2
[3-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-5-ethoxycarbonylmethoxy-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / dimethylformamide / 18 h / 20 °C

2: 66 percent / potassium carbonate / dimethylformamide / 20 h / Heating

3: 67 percent / piperidine / palladium phosphine / tetrahydrofuran / 2 h / 20 °C

4: 97 percent / iPr₂NEt; HATU / dimethylformamide / 1 h / 20 °C

With piperidine; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium phosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0614159