N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

Base Information

Chemical Name:N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide
CAS No.:281194-60-3
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

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Chemical Property of N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

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Technology Process of N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

There total 1 articles about N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 161203-15-2
N-Boc-glycine-pivalic acid mixed anhydride

: (2S)-2-tert-butoxycarbonylamino-3-methyl-1-phenyl-1-butanone hydrochloride

: 281194-60-3
N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

Guidance literature:: With triethylamine; In tetrahydrofuran;
DOI:10.1016/S0957-4166(00)00023-9

Reference yield: 90.0%

: 281194-60-3
N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

: 281194-61-4
(6S)-6-isopropyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide; With hydrogenchloride; In ethyl acetate; for 1h;

With potassium carbonate;
DOI:10.1016/S0040-4020(01)00553-1

Reference yield:

: 281194-60-3
N-1-[(1S)-1-benzoyl-2-methylpropyl]-2-[(tert-butoxycarbonyl)amino]acetamide

: (S)-6-Isopropyl-5-phenyl-3-[1-phenyl-meth-(Z)-ylidene]-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: HCl / ethyl acetate / 1 h

1.2: 90 percent / aq. K₂CO₃

2.1: 89 percent / 4-dimethylaminopyridine / tetrahydrofuran / 1.5 h / 0 °C

3.1: 88 percent / CH₂Cl₂ / 20 h / 20 °C

4.1: 11 percent / PPh₃; Pd(OAc)2; Bu₄NBr / K₂CO₃ / acetonitrile / 20 h / Heating

With hydrogenchloride; dmap; palladium diacetate; tetrabutylammomium bromide; triphenylphosphine; potassium carbonate; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile; 4.1: Heck reaction;
DOI:10.1016/S0040-4020(01)00553-1