(R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide

Base Information

• Chemical Name: (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide
• CAS No.: 1258204-84-0
• Molecular Formula: C₁₈H₁₈NOPS
• Molecular Weight: 327.387
• Mol file: 1258204-84-0.mol

Synonyms:(R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide

Chemical Property of (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide

There total 3 articles about (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(1-thiophenylethylidene)diphenylphosphinamide (694464-71-6) → (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide (1258204-84-0)

Guidance literature:

With C₄₅H₄₅ClFeN₂OP₂⁽¹⁺⁾*BF₄^(1-); potassium tert-butylate; isopropyl alcohol; at 28 ℃; for 0.05h; enantioselective reaction; Catalytic behavior;

DOI:10.1126/science.1244466

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide (1258204-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / Inert atmosphere

2: triethylamine / hexane; dichloromethane / Inert atmosphere

3: (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); potassium tert-butylate / isopropyl alcohol / 1 h / 30 °C / Inert atmosphere; Glovebox

With (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; triethylamine; In methanol; hexane; dichloromethane; isopropyl alcohol;

DOI:10.1021/ol302079q

Reference yield:

2-acetylthiophene oxime (1956-45-2,92313-45-6,92313-54-7) → (R)-N-(1-thiophenylethylidene)-p,p-diphenylphosphinic amide (1258204-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / hexane; dichloromethane / Inert atmosphere

2: (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); potassium tert-butylate / isopropyl alcohol / 1 h / 30 °C / Inert atmosphere; Glovebox

With (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); potassium tert-butylate; triethylamine; In hexane; dichloromethane; isopropyl alcohol;

DOI:10.1021/ol302079q

upstream raw materials:

N-(1-thiophenylethylidene)diphenylphosphinamide

2-Acetylthiophene

2-acetylthiophene oxime