(2R,3S)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

Base Information

Chemical Name:(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide
CAS No.:104947-14-0
Molecular Formula:C₃₀H₃₆N₄O₅S
Molecular Weight:564.706
Hs Code.:

Synonyms:(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

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Chemical Property of (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

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Technology Process of (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

There total 10 articles about (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 104947-13-9
(7-{(2S,3R)-2,3-Bis-[4-(1-ethoxy-ethoxy)-phenyl]-pentylsulfanyl}-heptyl)-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine

: 104947-14-0
(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

Guidance literature:: With Dowex-50; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00384a026

Reference yield:

: 4390-94-7
1,2-bis(4-methoxyphenyl)butanone

: 104947-14-0
(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

Guidance literature:: Multi-step reaction with 9 steps

1: TsOH

2: 0 °C

3: 1.) BH₃, 2.) NaOH, H₂O₂ / 1.) THF

4: Ph₃P, diisopropyl azodicarboxylate

5: LiAlH₄

6: KH

7: LiAlH₄

8: 52 percent / K₂CO₃ / ethanol / 17 h / 0 °C

9: 84 percent / Dowex-50 / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; Dowex-50; borane; dihydrogen peroxide; potassium hydride; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; In ethanol; dichloromethane;
DOI:10.1021/jm00384a026

Reference yield:

: 20965-27-9
7-bromo-heptanonitrile

: 104947-14-0
(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-7-aminoheptyl sulfide

Guidance literature:: Multi-step reaction with 4 steps

1: KH

2: LiAlH₄

3: 52 percent / K₂CO₃ / ethanol / 17 h / 0 °C

4: 84 percent / Dowex-50 / CH₂Cl₂ / 3 h / Ambient temperature

With lithium aluminium tetrahydride; Dowex-50; potassium hydride; potassium carbonate; In ethanol; dichloromethane;
DOI:10.1021/jm00384a026