f₄-Fmoc-Phe-OH

Base Information

• Chemical Name: f₄-Fmoc-Phe-OH
• CAS No.: 916686-40-3
• Molecular Formula: C₃₆H₂₇F₁₈NO₄
• Molecular Weight: 879.586
• Mol file: 916686-40-3.mol

Synonyms:f₄-Fmoc-Phe-OH

Chemical Property of f₄-Fmoc-Phe-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of f₄-Fmoc-Phe-OH

There total 1 articles about f₄-Fmoc-Phe-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + f4-Fmoc-OSu (916686-38-9) → f4-Fmoc-Phe-OH (916686-40-3)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0033-1339924

Reference yield: 96.0%

f4-Fmoc-Phe-OH (916686-40-3) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → f4-Fmoc-L-Phe-Gly-OMe

Guidance literature:

f₄-Fmoc-Phe-OH; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

glycine ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1055/s-0036-1588698

upstream raw materials:

L-phenylalanine

f₄-Fmoc-OSu