(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

Base Information

Chemical Name:(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester
CAS No.:1381815-38-8
Molecular Formula:C₄₃H₆₄N₄O₇Si
Molecular Weight:777.089
Hs Code.:

(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

Synonyms:(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

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Chemical Property of (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

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Technology Process of (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

There total 7 articles about (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52780-14-0,64382-14-5,134615-22-8,134615-24-0
(R)-1-(3-bromophenyl)ethanol

: 1381815-38-8
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 36 h / 45 °C / Inert atmosphere

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

3.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / acetonitrile / 16 h / 20 °C / Inert atmosphere

With dmap; trimethylsilyl trifluoromethanesulfonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 1381815-06-0
(R)-3-methoxy-hept-6-enoic acid methyl ester

: 1381815-38-8
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 2.5 h / 20 °C

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / acetonitrile / 16 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 112440-75-2
(R)-3-hydroxy-hept-6-enoic acid

: 1381815-38-8
(S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((R)-3-methoxy-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazin-3-carboxylic acid (R)-1-(3-vinyl-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 2.5 h / 20 °C

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / acetonitrile / 16 h / 20 °C / Inert atmosphere

With water; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;