4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

Base Information

Chemical Name:4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate
CAS No.:119154-94-8
Molecular Formula:C₃₁H₂₇ClN₈O₁₄S
Molecular Weight:803.12
Hs Code.:

4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

Synonyms:4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

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Chemical Property of 4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

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Technology Process of 4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

There total 3 articles about 4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65243-22-3
2-(2-chloroacetamidothiazol-4-yl)-2-(syn)-methoxyiminoacetyl chloride hydrochloride

: 4-Amino-2-[2-(4-nitro-benzyloxycarbonyl)-5-oxo-tetrahydro-furan-2-yl]-3-oxo-pyrazolidine-1-carboxylic acid 4-nitro-benzyl ester

: 119154-94-8
4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃; for 1h; Yield given;
DOI:10.1016/S0040-4020(01)85956-1

Reference yield:

: 119154-92-6
4-tert-butoxycarbonylamino-1-(4-nitrobenzyloxycarbonyl)pyrazolidin-3-one

: 119154-94-8
4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

2: trifluoroacetic acid / 1 h / 0 °C

3: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(01)85956-1

Reference yield:

: 119154-93-7
4-nitrobenzyl 2-<4-tert-butoxycarbonylamino-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

: 119154-94-8
4-nitrobenzyl 2-<4-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-1-(4-nitrobenzyloxycarbonyl)-3-oxopyrazolidin-2-yl>-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1 h / 0 °C

2: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; water;
DOI:10.1016/S0040-4020(01)85956-1