Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester
• CAS No.: 1053261-43-0
• Molecular Formula: C₃₆H₄₇FO₁₁
• Molecular Weight: 674.761
• Mol file: 1053261-43-0.mol

Synonyms:Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester

Chemical Property of Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester

There total 3 articles about Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-bromophenoxy)trimethylsilane (17878-44-3) → Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester (1053261-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / BF₃*OEt₂ / CH₂Cl₂ / 16 h

2: 1 M NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 4 h / Heating

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1039/C39950000645

Reference yield:

α-D-glucopyranose peracetylate (604-68-2) → Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester (1053261-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / BF₃*OEt₂ / CH₂Cl₂ / 16 h

2: 1 M NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 4 h / Heating

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1039/C39950000645

Reference yield:

1-O-(4′-bromophenyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (14581-80-7) + 3-fluoro-4-(1-decyloxy)phenyl boronic acid (175425-92-0) → Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4'-decyloxy-3'-fluoro-biphenyl-4-yloxy)-tetrahydro-pyran-3-yl ester (1053261-43-0)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 4h; Yield given; Heating;

DOI:10.1039/C39950000645

upstream raw materials:

1-O-(4′-bromophenyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

3-fluoro-4-(1-decyloxy)phenyl boronic acid

(4-bromophenoxy)trimethylsilane

α-D-glucopyranose peracetylate