(R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

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Chemical Name:(R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid
CAS No.:936703-26-3
Molecular Formula:C₃₈H₆₁NO₉
Molecular Weight:675.904
Hs Code.:

Synonyms:(R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

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Chemical Property of (R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

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Technology Process of (R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

There total 9 articles about (R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 936703-49-0
(2S,3S)-1-((R)-1-(allyloxy)-14-methyl-1-oxopentadecan-3-yl)-4-cyclohexyl-3-(benzyloxy)-2-(tert-butoxycarbonylamino)succinate

: 936703-26-3
(R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

Guidance literature:: With phenylsilane; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ja068455x

Reference yield:

: 106787-53-5
11-methyl-dodec-1-ene

: 936703-26-3
(R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / Grubbs catalyst second generation / CH₂Cl₂ / 24 h / 50 °C

2.1: 98 percent / H₂ / Pd/C / ethanol / 24 h

3.1: TFA / CH₂Cl₂ / 20 °C

3.2: 90 percent / K₂CO₃ / methanol / 12 h

4.1: aq. Cs₂CO₃ / methanol / 0.25 h / 20 °C

4.2: 90 percent / dimethylformamide / 12 h

5.1: 84 percent / DMAP; EDCl / CH₂Cl₂ / 15 h / -15 - 20 °C

6.1: 98 percent / PhSiH₃ / PdCl₂(PPh₃)2; PPh₃ / CH₂Cl₂ / 12 h / 20 °C

With dmap; phenylsilane; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; triphenylphosphine; In methanol; ethanol; dichloromethane;
DOI:10.1021/ja068455x

Reference yield:

: 936703-48-9
(S)-tert-butyl 3-acetoxy-14-methylpentadec-4-enoate

: 936703-26-3
(R)-3-((2S,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-(cyclohexyloxy)-4-oxobutyloxy)-14-methylpentadecanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / H₂ / Pd/C / ethanol / 24 h

2.1: TFA / CH₂Cl₂ / 20 °C

2.2: 90 percent / K₂CO₃ / methanol / 12 h

3.1: aq. Cs₂CO₃ / methanol / 0.25 h / 20 °C

3.2: 90 percent / dimethylformamide / 12 h

4.1: 84 percent / DMAP; EDCl / CH₂Cl₂ / 15 h / -15 - 20 °C

5.1: 98 percent / PhSiH₃ / PdCl₂(PPh₃)2; PPh₃ / CH₂Cl₂ / 12 h / 20 °C

With dmap; phenylsilane; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; triphenylphosphine; In methanol; ethanol; dichloromethane;
DOI:10.1021/ja068455x