1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

Base Information

Chemical Name:1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine
CAS No.:162379-33-1
Molecular Formula:C₃₂H₃₉NO₅S
Molecular Weight:549.731
Hs Code.:

Synonyms:1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

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Chemical Property of 1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

Chemical Property:

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Technology Process of 1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

There total 7 articles about 1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 162379-28-4
1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methylidene>piperidine

: 162379-33-1
1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; for 3h; pH = 4;
DOI:10.1016/0040-4020(95)00036-8

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 162379-33-1
1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / Ambient temperature

2: 82 percent / 1.) boron trifluoride etherate, 2.) butyllithium, TFAA / tetrahydrofuran; hexane / 0.03 h / -78 °C

3: 96 percent / Lawesson's reagent / toluene / 4 h / Heating

4: 94 percent / Ph₃P, TEA / acetonitrile; CH₂Cl₂ / 72 h / Ambient temperature

5: 97 percent / acetic acid, NaCNBH₃ / methanol / 3 h / pH = 4

With Lawessons reagent; n-butyllithium; TEA; boron trifluoride diethyl etherate; sodium cyanoborohydride; acetic acid; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1016/0040-4020(95)00036-8

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 162379-33-1
1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-<(ethoxycarbonyl)methyl>piperidine

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / PDC / CH₂Cl₂ / 5 h

2: toluene / 2 h / Ambient temperature

3: 82 percent / 1.) boron trifluoride etherate, 2.) butyllithium, TFAA / tetrahydrofuran; hexane / 0.03 h / -78 °C

4: 96 percent / Lawesson's reagent / toluene / 4 h / Heating

5: 94 percent / Ph₃P, TEA / acetonitrile; CH₂Cl₂ / 72 h / Ambient temperature

6: 97 percent / acetic acid, NaCNBH₃ / methanol / 3 h / pH = 4

With Lawessons reagent; dipyridinium dichromate; n-butyllithium; TEA; boron trifluoride diethyl etherate; sodium cyanoborohydride; acetic acid; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1016/0040-4020(95)00036-8