3-(2H-TETRAZOL-5-YL)-PHENYL-BORONIC ACID

Base Information

• Chemical Name: 3-(2H-TETRAZOL-5-YL)-PHENYL-BORONIC ACID
• CAS No.: 775351-30-9
• Molecular Formula: C7H7 B N4 O2
• Molecular Weight: 189.969
• Hs Code.: 2933990090
• Mol file: 775351-30-9.mol

Synonyms:Boronicacid, [3-(1H-tetrazol-5-yl)phenyl]- (9CI); [3-(1H-Tetrazol-5-yl)phenyl]boronicacid; [3-(Tetrazol-5-yl)phenyl]boronic acid

Chemical Property of 3-(2H-TETRAZOL-5-YL)-PHENYL-BORONIC ACID

Chemical Property:

• Vapor Pressure: 1.57E-11mmHg at 25°C
• Refractive Index: 1.641
• Boiling Point: 517.4°C at 760 mmHg
• PKA: 4.31±0.10(Predicted)
• Flash Point: 266.7°C
• PSA: 94.92000
• Density: 1.51g/cm³
• LogP: -1.45350
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(Tetrazol-5-yl)phenylboronic acid Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2H-TETRAZOL-5-YL)-PHENYL-BORONIC ACID

There total 1 articles about 3-(2H-TETRAZOL-5-YL)-PHENYL-BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

(3‐cyanophenyl)boronic acid (150255-96-2) → (3-(1H-tetrazol-5-yl)phenyl)boronic acid (775351-30-9)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 2.5h;

Reference yield: 39.0%

3-(4-bromophenyl)-4-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4H-1,2,4-triazole + (3-(1H-tetrazol-5-yl)phenyl)boronic acid (775351-30-9) → 5-[4'-(4-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4H-1,2,4-triazol-3-yl)-3-biphenylyl]-1H-tetrazole

Guidance literature:

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield: 16.0%

3-(3-(3-bromophenyl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one (1616372-71-4) + (3-(1H-tetrazol-5-yl)phenyl)boronic acid (775351-30-9) → 3-(3-(3'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one (1616372-60-1)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 85 ℃; for 24h; Inert atmosphere;

upstream raw materials:

(3‐cyanophenyl)boronic acid

Downstream raw materials:

{(E)-(1S,2S)-1-((S)-3-Fluoro-pyrrolidine-1-carbonyl)-2-[3'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-pent-3-enyl}-carbamic acid tert-butyl ester

3-(3-(3'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

3-(3-(3'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)propyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one