3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

Base Information

Chemical Name:3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester
CAS No.:477332-13-1
Molecular Formula:C₄₂H₅₃N₃O₉Si
Molecular Weight:771.983
Hs Code.:

3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid <i>tert</i>-butyl ester

Synonyms:3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

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Chemical Property of 3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

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Technology Process of 3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

There total 17 articles about 3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 477332-12-0
(S)-3-(2''-Methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-butyraldehyde

: 3-(tert-butyl-diphenyl-silanyloxy)-6-iodo-hex-5-enoic acid tert-butyl ester

: 477332-13-1
3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

Guidance literature:: With chromium dichloride; nickel dichloride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(02)01553-8

Reference yield:

: 108100-50-1,111058-62-9,56936-16-4
(+/-)-tert-butyl 3,4-epoxybutanoate

: 477332-13-1
3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / (R,R)-Salen-Co; aq. AcOH / 0 - 20 °C

2: 76 percent / copper(I) iodide

3: 98 percent / imidazole

4: ozone; Me₂S

5: Cr₂Cl₂

6: 78 percent / CrCl₂; NiCl₂ / tetrahydrofuran; dimethylsulfoxide

With 1H-imidazole; chromium dichloride; copper(l) iodide; dimethylsulfide; Cr₂Cl₂; (R,R)-Salen-Co; ozone; acetic acid; nickel dichloride; In tetrahydrofuran; dimethyl sulfoxide; 5: Takai iodo-olefination / 6: Kishi-Nozaki coupling;
DOI:10.1016/S0040-4039(02)01553-8

Reference yield:

: 108100-50-1
(R)-tert-butyl 3,4-epoxybutanoate

: 477332-13-1
3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / copper(I) iodide

2: 98 percent / imidazole

3: ozone; Me₂S

4: Cr₂Cl₂

5: 78 percent / CrCl₂; NiCl₂ / tetrahydrofuran; dimethylsulfoxide

With 1H-imidazole; chromium dichloride; copper(l) iodide; dimethylsulfide; Cr₂Cl₂; ozone; nickel dichloride; In tetrahydrofuran; dimethyl sulfoxide; 4: Takai iodo-olefination / 5: Kishi-Nozaki coupling;
DOI:10.1016/S0040-4039(02)01553-8