1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

Base Information

Chemical Name:1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one
CAS No.:1242049-85-9
Molecular Formula:C₂₂H₂₁N₃O
Molecular Weight:343.428
Hs Code.:

Synonyms:1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

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Chemical Property of 1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

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Technology Process of 1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

There total 3 articles about 1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 603-76-9
1-methylindole

: 99802-91-2
2-cinnamoyl-1-methyl-1H-imidazole

: 1242049-85-9
1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

Guidance literature:: With copper(II) nitrate trihydrate; In aq. buffer; at 20 ℃; for 72h; pH=6.5; Reagent/catalyst; enantioselective reaction;
DOI:10.1021/acs.joc.9b02718

Reference yield: 80.0%

: 860772-43-6
(E)-1-(1-methyl-1H-imidazole-2-yl)-3-phenylprop-2-en-1-one

: 603-76-9
1-methylindole

: 1242049-85-9
1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

Guidance literature:: With 4,4'-dimethyl-2,2'-bipyridines; copper(II) nitrate trihydrate; In acetonitrile; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1002/anie.201306232

Reference yield:

: 85692-37-1
1-(1-methyl-1H-imidazol-2-yl)ethan-1-one

: 1242049-85-9
1-(1-methyl-1H-imidazol-2-yl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 48 h / 20 °C / Inert atmosphere

2: 4,4'-dimethyl-2,2'-bipyridines; copper(II) nitrate trihydrate / acetonitrile / 72 h / 20 °C / Inert atmosphere

With 4,4'-dimethyl-2,2'-bipyridines; copper(II) nitrate trihydrate; potassium hydroxide; In ethanol; acetonitrile; 2: |Friedel-Crafts Alkylation;
DOI:10.1002/anie.201306232