(2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

Base Information

Chemical Name:(2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide
CAS No.:1027136-90-8
Molecular Formula:C₂₉H₃₀N₂O₅S
Molecular Weight:518.634
Hs Code.:

Synonyms:(2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

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Chemical Property of (2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

Chemical Property:

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Technology Process of (2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

There total 7 articles about (2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylthio)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

: 1027136-90-8
(2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 672328-09-5
(5S)-2-(4-bromophenyl)-5-isobutyl-1,3-dioxolan-4-one

: 1027136-90-8
(2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: zinc(II) chloride / diethyl ether / 2 h / 0 °C

2: triethylamine; (1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium hexafluoro-lambda5-phosphanuide / N,N-dimethyl-formamide / 3 h / 20 °C

3: potassium carbonate; potassium iodide / [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II)complex / methoxybenzene / 18 h / 90 °C / 760.05 Torr

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; (1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium hexafluoro-lambda5-phosphanuide; potassium iodide; zinc(II) chloride; [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II)complex; In diethyl ether; dichloromethane; methoxybenzene; N,N-dimethyl-formamide;

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 1027136-90-8
(2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-{4-[4-(methylsulfonyl)benzoyl]phenyl}(phenyl)methyl]oxy}pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridinium p-toluenesulfonate / toluene / 24 h / Heating / reflux

2: zinc(II) chloride / diethyl ether / 2 h / 0 °C

3: triethylamine; (1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium hexafluoro-lambda5-phosphanuide / N,N-dimethyl-formamide / 3 h / 20 °C

4: potassium carbonate; potassium iodide / [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II)complex / methoxybenzene / 18 h / 90 °C / 760.05 Torr

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

With pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; (1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium hexafluoro-lambda5-phosphanuide; potassium iodide; zinc(II) chloride; [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II)complex; In diethyl ether; dichloromethane; methoxybenzene; N,N-dimethyl-formamide; toluene;