5-chlorothiophene-2-carboxaldehyde-N⁽⁴⁾-phenyl-thiosemicarbazone

Base Information

• Chemical Name: 5-chlorothiophene-2-carboxaldehyde-N⁽⁴⁾-phenyl-thiosemicarbazone
• CAS No.: 1344030-17-6
• Molecular Formula: C₁₂H₁₀ClN₃S₂
• Molecular Weight: 295.817
• Mol file: 1344030-17-6.mol

Synonyms:5-chlorothiophene-2-carboxaldehyde-N⁽⁴⁾-phenyl-thiosemicarbazone

Chemical Property of 5-chlorothiophene-2-carboxaldehyde-N⁽⁴⁾-phenyl-thiosemicarbazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chlorothiophene-2-carboxaldehyde-N⁽⁴⁾-phenyl-thiosemicarbazone

There total 3 articles about 5-chlorothiophene-2-carboxaldehyde-N⁽⁴⁾-phenyl-thiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-Chloro-2-thiophenecarboxaldehyde (7283-96-7) + 4-Phenyl-3-thiosemicarbazide (5351-69-9) → 5-chlorothiophene-2-carboxaldehyde-N(4)-phenyl-thiosemicarbazone (1344030-17-6)

Guidance literature:

In methanol; for 10.25h; Reflux;

DOI:10.1016/j.ejmech.2011.09.031

Reference yield:

aniline (62-53-3) → 5-chlorothiophene-2-carboxaldehyde-N(4)-phenyl-thiosemicarbazone (1344030-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / chloroform / 20 °C

2: hydrazine hydrate / diethyl ether / 20 °C

3: methanol / 10.25 h / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; diethyl ether; chloroform;

DOI:10.1016/j.ejmech.2011.09.031

Reference yield:

phenyl isothiocyanate (103-72-0) → 5-chlorothiophene-2-carboxaldehyde-N(4)-phenyl-thiosemicarbazone (1344030-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / diethyl ether / 20 °C

2: methanol / 10.25 h / Reflux

With hydrazine hydrate; In methanol; diethyl ether;

DOI:10.1016/j.ejmech.2011.09.031

upstream raw materials:

5-Chloro-2-thiophenecarboxaldehyde

4-Phenyl-3-thiosemicarbazide

phenyl isothiocyanate

aniline