5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine

Base Information

• Chemical Name: 5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine
• CAS No.: 1313227-60-9
• Molecular Formula: C₁₆H₂₅NO₂Si
• Molecular Weight: 291.466
• Mol file: 1313227-60-9.mol

Synonyms:5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine

Chemical Property of 5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine

There total 1 articles about 5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

t-butyldimethylsiyl triflate (69739-34-0) + 3-methyl-5-phenyl-4,5-dihydroisoxazole 2-oxide (127525-90-0) → 5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine (1313227-60-9)

Guidance literature:

With triethylamine; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2011.04.078

Reference yield:

N-Bromosuccinimide (128-08-5) + 5-(phenyl)-2-(tert-butyldimethylsilyloxy)-3-methyleneisoxazolidine (1313227-60-9) → 1-(rac-(3S,5S)-3-bromomethyl-2-(tert-butyldimethylsilyloxy)-5-phenylisoxazolidine-3-yl)-pyrrolidine-2,5-dione + 1-(rac-(3S,5R)-3-bromomethyl-2-(tert-butyldimethylsilyloxy)-5-phenylisoxazolidine-3-yl)-pyrrolidine-2,5-dione

Guidance literature:

In dichloromethane; at -78 - 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1016/j.tet.2011.04.078

upstream raw materials:

t-butyldimethylsiyl triflate

3-methyl-5-phenyl-4,5-dihydroisoxazole 2-oxide