(R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

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Chemical Name:(R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid
CAS No.:1382976-53-5
Molecular Formula:C₂₆H₂₀ClF₂N₃O₅
Molecular Weight:527.912
Hs Code.:

Synonyms:(R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

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Chemical Property of (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

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Technology Process of (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

There total 3 articles about (R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₁BrFN₃O₅

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1382976-53-5
(R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; In ethanol; toluene; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 842973-74-4
3-(2-fluorophenyl)isoxazole-5-carboxylic acid

: 1382976-53-5
(R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 0.25 h

1.2: 0.25 h / 20 °C

2.1: potassium carbonate; water; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); water; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: (R)-3-[N-(4-bromobenzyl)hydrazino]-2-hydroxypropionic acid ethyl ester

: 1382976-53-5
(R)-3-{N-(5'-chloro-2'-fluorobiphenyl-4-ylmethyl)-N'-[3-(2-fluorophenyl)isoxazole-5-carbonyl]-hydrazino}-2-hydroxypropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 0.25 h

1.2: 0.25 h / 20 °C

2.1: potassium carbonate; water; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); water; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene;