(2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

Base Information

Chemical Name:(2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)
CAS No.:1571076-49-7
Molecular Formula:C₂₆H₃₄N₄O₆
Molecular Weight:498.579
Hs Code.:

Synonyms:(2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

Suppliers and Price of (2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

There total 6 articles about (2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1571076-48-6
(2S,2'R)-dibenzyl 2,2'-(((2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(azanediyl))bis(carbonyl))bis(pyrrolidine-1-carboxylate)

: 1571076-49-7
(2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 1h; under 760.051 Torr;
DOI:10.1055/s-0033-1339928

Reference yield:

: 34261-55-7
5,5'-dibromo-2,2'-dihydroxybiphenyl

: 1571076-49-7
(2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; nitric acid / 10 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 20 - 50 °C / Inert atmosphere

2.2: 8 h / 50 °C

3.1: 5%-palladium/activated carbon; hydrazine hydrate / ethanol / 6 h / Reflux; Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

With 5%-palladium/activated carbon; palladium 10% on activated carbon; hydrogen; nitric acid; sodium hydride; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-0033-1339928

Reference yield:

: 1571076-47-5
2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diamine

: 1571076-49-7
(2S,2'R)-N,N'-(2,2'-bis(methoxymethoxy)-[1,1'-biphenyl]-3,3'-diyl)bis(pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1055/s-0033-1339928