9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

Base Information

Chemical Name:9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine
CAS No.:139607-45-7
Molecular Formula:C₃₂H₂₉ClN₄O₃
Molecular Weight:553.06
Hs Code.:

Synonyms:9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

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Chemical Property of 9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

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Technology Process of 9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

There total 12 articles about 9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 139607-44-6
(1β,2α,5α)-1-N-(5-amino-6-chloropyrimidin-4-yl)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopentenylamine

: 122-51-0
orthoformic acid triethyl ester

: 139607-45-7
9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

Guidance literature:: With hydrogenchloride; Ambient temperature;
DOI:10.1021/jo00033a031

Reference yield:

: (1α,4α,5β)-1-(benzyloxy)-3-<(benzyloxy)methyl>-4-hydroxy-5-azido-2-cyclopentene

: 139607-45-7
9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH / 1) DMF, oil, 30 min, 2) 30 min

2: 86 percent / H₂ / Lindlar-catalyst / methanol / 760 Torr

3: 51 percent / Et₃N / butan-1-ol / 48 h / Heating

4: 83 percent / conc. HCl / Ambient temperature

With hydrogenchloride; hydrogen; sodium hydride; triethylamine; Lindlar's catalyst; In methanol; butan-1-ol;
DOI:10.1021/jo00033a031

Reference yield:

: (1α,4α,5β)-1-(benzyloxy)-3-<(benzyloxy)methyl>-4-(acetyloxy)-5-azido-2-cyclopentene

: 139607-45-7
9-<(1β,2α,5α)-2,5-bis(benzyloxy)-3-<(benzyloxy)methyl>-3-cyclopenten-1-yl>-6-chloropurine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / NaOMe, MeOH / 0.5 h / Ambient temperature

2: 1) NaH / 1) DMF, oil, 30 min, 2) 30 min

3: 86 percent / H₂ / Lindlar-catalyst / methanol / 760 Torr

4: 51 percent / Et₃N / butan-1-ol / 48 h / Heating

5: 83 percent / conc. HCl / Ambient temperature

With hydrogenchloride; methanol; hydrogen; sodium methylate; sodium hydride; triethylamine; Lindlar's catalyst; In methanol; butan-1-ol;
DOI:10.1021/jo00033a031