2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

Base Information

Chemical Name:2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate
CAS No.:1272656-42-4
Molecular Formula:C₂₁H₃₅N₃O₇
Molecular Weight:441.525
Hs Code.:

Synonyms:2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

There total 1 articles about 2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177947-96-5
tert-butyl 3-formylazetidine-1-carboxylate

: 1272656-42-4
2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / Reflux; Inert atmosphere

2: triethylamine / tetrahydrofuran / Inert atmosphere

3: hydrogen / ethanol / Inert atmosphere

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; dichloromethane; benzene;
DOI:10.1021/jm4013104

Reference yield:

: 1272656-42-4
2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

: 1272656-35-5
1,1-dimethylethyl 6-{N-[(methyloxy)carbonyl]-L-valyl}-7-(4-{4′-[2-((2S)-1-{N-[(methyloxy)carbonyl]-L-valyl}-2-pyrrolidinyl)-1H-imidazol-4-yl]-4-biphenylyl}-1H-imidazol-2-yl)-2,6-diazaspiro[3.4]octane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: ammonium acetate / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

With ammonium acetate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4013104

Reference yield:

: 1272656-42-4
2-(1,1-dimethylethyl) 7-ethyl 6-(N-[(methyloxy)carbonyl]-L-valyl)-2,6-diazaspiro[3.4]octane-2,7-dicarboxylate

: 1272656-37-7
1,1-dimethylethyl 6-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-7-(((2-(4'-(2-((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-4-biphenylyl)-2-oxoethyl)amino)carbonyl)-2,6-diazaspiro[3.4]octane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4013104