benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

Base Information

Chemical Name:benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate
CAS No.:213539-62-9
Molecular Formula:C₁₆H₂₃NO₆SSi
Molecular Weight:385.513
Hs Code.:

Synonyms:benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

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Technology Process of benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

There total 1 articles about benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 151776-97-5
D-N-SES-Ser-OBn

: 213539-62-9
benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jo980765d

Reference yield:

: 213539-62-9
benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

: 213539-65-2
benzyl (2S,3S)-4-(1,3-dioxan-2-yl)-2-(N-(N-(2-trimethylsilylethanesulfonyl)-D-serinyl)-N'-(tert-butyloxycarbonyl)hydrazino)-3-((tert-butyldimethylsilyl)oxy)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 23 °C

2: oxalyl chloride, DMF / CH₂Cl₂ / 2 h / 23 °C

3: K₂CO₃ / CH₂Cl₂ / 2 h / 0 °C

4: 64 percent / Cs₂CO₃ / methanol / 0.58 h / 25 °C

With oxalyl dichloride; hydrogen; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo980765d

Reference yield:

: 213539-62-9
benzyl (4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carboxylate

: 213539-64-1
benzyl (2S,3S)-4-(1,3-dioxan-2-yl)-2-(N-((4R)-2-oxo-3-(2-trimethylsilylethanesulfonyl)-1,3-oxazolidine-4-carbonyl)-N'-(tert-butyloxycarbonyl)hydrazino)-3-((tert-butyldimethylsilyl)oxy)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 23 °C

2: oxalyl chloride, DMF / CH₂Cl₂ / 2 h / 23 °C

3: K₂CO₃ / CH₂Cl₂ / 2 h / 0 °C

With oxalyl dichloride; hydrogen; potassium carbonate; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo980765d