(2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Base Information

Chemical Name:(2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol
CAS No.:1619984-01-8
Molecular Formula:C₂₂H₃₅NO₃
Molecular Weight:361.525
Hs Code.:

Synonyms:(2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

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Chemical Property of (2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

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Technology Process of (2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

There total 3 articles about (2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1619984-66-5
(2R,4aS,8aS)-1-{[(3,5-dimethoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619984-01-8
(2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Guidance literature:: With sodium thioethylate; In N,N-dimethyl-formamide; at 160 ℃; for 2h; Microwave irradiation; Sealed tube;

Reference yield:

: 52617-99-9
(+)-drimane-8,11-diol

: 1619984-01-8
(2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18 h / 20 °C / Inert atmosphere

3: sodium thioethylate / N,N-dimethyl-formamide / 2 h / 160 °C / Microwave irradiation; Sealed tube

With sodium tris(acetoxy)borohydride; pyridinium chlorochromate; sodium thioethylate; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1619984-65-4
(2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalene-1-carbaldehyde

: 1619984-01-8
(2 R,4aS,8aS)-1-{[(3-hydroxy-5-methoxyphenyl)amino]methyl}-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 18 h / 20 °C / Inert atmosphere

2: sodium thioethylate / N,N-dimethyl-formamide / 2 h / 160 °C / Microwave irradiation; Sealed tube

With sodium tris(acetoxy)borohydride; sodium thioethylate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;