{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

Base Information

Chemical Name:{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester
CAS No.:75115-35-4
Molecular Formula:C₅₂H₇₂N₁₂O₁₀
Molecular Weight:1025.22
Hs Code.:

{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

Synonyms:{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

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Chemical Property of {4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

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Technology Process of {4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

There total 8 articles about {4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 75115-34-3
7-({(2S,5R,8S,11S,14S,19S)-19-Amino-2-benzyl-11-(1-hydroxy-ethyl)-5-(1H-indol-3-ylmethyl)-3,6,9,12,20-pentaoxo-8-[4-(pyridin-4-ylmethoxycarbonylamino)-butyl]-1,4,7,10,13-pentaaza-cycloicosane-14-carbonyl}-amino)-heptanoic acid methyl ester

: 75115-35-4
{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

Guidance literature:: With N,N-dimethyl-formamide; hydrazine; at 23 ℃; for 1.66667h;
DOI:10.1021/ja00541a025

Reference yield:

: 17994-94-4
methyl 7-aminoheptanoate hydrochloride

: 75115-35-4
{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / DPPA, DIPEA, pH 7.0 / dimethylformamide / 1.) - 20 deg C, 96 h, 2.) 5 deg c, 48 h

2: HF, anisol / 0.5 h / 0 °C

3: 54 percent / NH₂NH₂, DMF / 1.67 h / 23 °C

With diphenyl-phosphinic acid; hydrogen fluoride; methoxybenzene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; hydrazine; In N,N-dimethyl-formamide;
DOI:10.1021/ja00541a025

Reference yield:

: C₆₀H₆₈N₁₂O₁₃

: 75115-35-4
{4-[(3S,6S,9R,12S,15S,20S)-15-Amino-12-benzyl-20-(6-hydrazinocarbonyl-hexylcarbamoyl)-3-(1-hydroxy-ethyl)-9-(1H-indol-3-ylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-6-yl]-butyl}-carbamic acid pyridin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DIPEA, pH 7.0 - 7.2 / dimethylformamide / 1.) - 20 deg C, 24 h, 2.) 5 deg C, 72 h

2: 95 percent / DPPA, DIPEA, pH 7.0 / dimethylformamide / 1.) - 20 deg C, 96 h, 2.) 5 deg c, 48 h

3: HF, anisol / 0.5 h / 0 °C

4: 54 percent / NH₂NH₂, DMF / 1.67 h / 23 °C

With diphenyl-phosphinic acid; hydrogen fluoride; methoxybenzene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; hydrazine; In N,N-dimethyl-formamide;
DOI:10.1021/ja00541a025