C₃₇H₄₈O₇Si

Base Information

Chemical Name:C₃₇H₄₈O₇Si
CAS No.:615285-16-0
Molecular Formula:C₃₇H₄₈O₇Si
Molecular Weight:632.869
Hs Code.:

C<sub>37</sub>H<sub>48</sub>O<sub>7</sub>Si

Synonyms:C₃₇H₄₈O₇Si

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Chemical Property of C₃₇H₄₈O₇Si

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Technology Process of C₃₇H₄₈O₇Si

There total 26 articles about C₃₇H₄₈O₇Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 615284-89-4
C₃₇H₄₈O₇Si

: 615285-16-0
C₃₇H₄₈O₇Si

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; tert-butyldimethylsilyl chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - -25 ℃; for 72h;
DOI:10.1002/anie.200351825

Reference yield:

: 392663-00-2
(E)-(S)-6-Benzyloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methyl-hex-3-en-2-one

: 615285-16-0
C₃₇H₄₈O₇Si

Guidance literature:: Multi-step reaction with 27 steps

1.1: 98 percent / LiI; LiAlH₄ / diethyl ether / -100 - 0 °C

2.1: 97 percent / AcOH / H₂O / 5 h / 40 °C

3.1: 70 percent / NaHCO₃; N-iodosuccinimide / tetrahydrofuran / 36 h / 0 °C

4.1: 99 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 10 h / 25 °C

5.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

6.1: 99 percent / H₂; Raney-Ni catalyst / ethanol / 1 h / 25 °C

7.1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 3 h / 25 °C

8.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 25 °C

9.1: Mg / tetrahydrofuran / 2 h / 25 °C

9.2: tetrahydrofuran / 2 h / -78 - 0 °C

10.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 25 °C

11.1: 98 percent / triethyl orthoformate; p-TsOH / 2.5 h / 55 °C

12.1: N-methylmorpholine-N-oxide; OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 14 h / 25 °C

12.2: 100 percent / NaIO₄; aq. saline solution buffer / tetrahydrofuran; 2-methyl-propan-2-ol / 5 h / 25 °C

13.1: n-BuLi / tetrahydrofuran; toluene / 3 h / -30 °C

13.2: tetrahydrofuran / 1 h / -30 °C

14.1: 13.2 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 0 °C

15.1: 85 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 - -30 °C

16.1: 95 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 25 °C

17.1: 91 percent / 2,6-lutidine; N-bromosuccinimide / acetonitrile; H₂O / 2 h / 25 °C

18.1: 92 percent / NaBH₄ / methanol / 0.08 h / -5 °C

19.1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

20.1: 80 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 0 °C

21.1: 83 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 1 h / -78 °C

22.1: 90 percent / Pd(PPh₃)4; n-Bu₃SnH / tetrahydrofuran / 0.75 h / 25 °C

23.1: 92 percent / diisobutylaluminum hydride / CH₂Cl₂ / 0.33 h / -78 °C

24.1: 92 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 0 °C

25.1: diethyl ether; tetrahydrofuran / 1 h / 25 °C

26.1: pyridine; 4-DMAP / CH₂Cl₂ / 3 h / 0 °C

27.1: 82 percent / lithium diisopropylamide; hexamethylphosphoramide; t-BuMe₂SiCl / tetrahydrofuran / 72 h / -78 - 25 °C

With pyridine; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; N-Bromosuccinimide; N-iodo-succinimide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; Raney-Ni catalyst; hydrogen; tri-n-butyl-tin hydride; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; tert-butyldimethylsilyl chloride; acetic acid; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; orthoformic acid triethyl ester; trifluoroacetic acid; lithium iodide; lithium diisopropyl amide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; 20.1: Swern oxidation / 24.1: Swern oxidation / 27.1: Ireland-Claisen rearrangement;
DOI:10.1021/ja0547477

Reference yield:

: 392663-05-7
(2R,3S,5R)-2-((1S,2R)-3-Benzyloxy-1-iodo-2-methyl-propyl)-5-hydroxymethyl-tetrahydro-furan-3-ol

: 615285-16-0
C₃₇H₄₈O₇Si

Guidance literature:: Multi-step reaction with 24 steps

1.1: 99 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 10 h / 25 °C

2.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 99 percent / H₂; Raney-Ni catalyst / ethanol / 1 h / 25 °C

4.1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 3 h / 25 °C

5.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 25 °C

6.1: Mg / tetrahydrofuran / 2 h / 25 °C

6.2: tetrahydrofuran / 2 h / -78 - 0 °C

7.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 4 h / 0 - 25 °C

8.1: 98 percent / triethyl orthoformate; p-TsOH / 2.5 h / 55 °C

9.1: N-methylmorpholine-N-oxide; OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 14 h / 25 °C

9.2: 100 percent / NaIO₄; aq. saline solution buffer / tetrahydrofuran; 2-methyl-propan-2-ol / 5 h / 25 °C

10.1: n-BuLi / tetrahydrofuran; toluene / 3 h / -30 °C

10.2: tetrahydrofuran / 1 h / -30 °C

11.1: 13.2 g / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 0 °C

12.1: 85 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 - -30 °C

13.1: 95 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 25 °C

14.1: 91 percent / 2,6-lutidine; N-bromosuccinimide / acetonitrile; H₂O / 2 h / 25 °C

15.1: 92 percent / NaBH₄ / methanol / 0.08 h / -5 °C

16.1: 56 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

17.1: 80 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 0 °C

18.1: 83 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 1 h / -78 °C

19.1: 90 percent / Pd(PPh₃)4; n-Bu₃SnH / tetrahydrofuran / 0.75 h / 25 °C

20.1: 92 percent / diisobutylaluminum hydride / CH₂Cl₂ / 0.33 h / -78 °C

21.1: 92 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 - 0 °C

22.1: diethyl ether; tetrahydrofuran / 1 h / 25 °C

23.1: pyridine; 4-DMAP / CH₂Cl₂ / 3 h / 0 °C

24.1: 82 percent / lithium diisopropylamide; hexamethylphosphoramide; t-BuMe₂SiCl / tetrahydrofuran / 72 h / -78 - 25 °C

With pyridine; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; Raney-Ni catalyst; hydrogen; tri-n-butyl-tin hydride; potassium hexamethylsilazane; diisobutylaluminium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; tert-butyldimethylsilyl chloride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; orthoformic acid triethyl ester; trifluoroacetic acid; lithium diisopropyl amide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; 17.1: Swern oxidation / 21.1: Swern oxidation / 24.1: Ireland-Claisen rearrangement;
DOI:10.1021/ja0547477