7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Base Information

Chemical Name:7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one
CAS No.:1390655-34-1
Molecular Formula:C₂₄H₂₀Cl₂F₂N₆O
Molecular Weight:517.365
Hs Code.:

Synonyms:7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Suppliers and Price of 7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

There total 17 articles about 7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1390655-34-1
7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / 5 h / 20 °C / Cooling with ice

2.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: 1,4-dioxane / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 15 h / 120 °C

10.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol; tetrahydrofuran / 15 h / 120 °C / Inert atmosphere; Sealed tube

11.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With n-butyllithium; thionyl chloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; toluene-4-sulfonic acid; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 1390656-77-5
tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-2,5-difluorophenyl)piperazine-1-carboxylate

: 1390655-34-1
7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 1390655-34-1
7-(2,6-dichlorobenzyl)-5-{[2,5-difluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; ethylene dibromide / tetrahydrofuran / 0.5 h / 65 °C / Inert atmosphere

1.2: 2.33 h

2.1: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol; tetrahydrofuran / 15 h / 120 °C / Inert atmosphere; Sealed tube

3.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With chloro-trimethyl-silane; potassium tert-butylate; ethylene dibromide; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;