(4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide

Base Information

• Chemical Name: (4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide
• CAS No.: 1095278-63-9
• Molecular Formula: C₂₉H₂₉NO₃P₂
• Molecular Weight: 501.502
• Mol file: 1095278-63-9.mol

Synonyms:(4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide

Chemical Property of (4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide

There total 1 articles about (4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

C16H18O2P2 + N-(benzylidene)aniline N-oxide (1137-96-8,26505-49-7,201024-81-9) → (4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide (1095278-63-9) + (4SP,5RP)-(+)-bis-(4S,5R)-[methyl(phenyl)phosphinyl]-(N,3S)-diphenylisoxazolidine dioxide (1095278-59-3)

Guidance literature:

In toluene; at 125 ℃; for 0.666667h; optical yield given as %de; stereoselective reaction; Microwave irradiation;

DOI:10.1039/b810573a

Reference yield:

(4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide (1095278-63-9) → (4RP,5SP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-(diphenyl)isoxazolidine (1095278-65-1)

Guidance literature:

With titanium(IV) isopropylate; polymethylhydrosiloxane; In tetrahydrofuran; at 66 ℃; for 17h; stereospecific reaction;

DOI:10.1039/b810573a

Reference yield:

(4SP,5RP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-diphenylisoxazolidine dioxide (1095278-63-9) → C29H29NOP2 (1095278-65-1)

Guidance literature:

With titanium(IV) isopropylate; polymethylhydrosiloxane; In tetrahydrofuran; at 66 ℃; for 17h; stereospecific reaction;

DOI:10.1039/b810573a

upstream raw materials:

N-(benzylidene)aniline N-oxide

Downstream raw materials:

(4RP,5SP)-(-)-bis-(4R,5S)-[methyl(phenyl)phosphinyl]-(N,3R)-(diphenyl)isoxazolidine

C₂₉H₂₉NOP₂