N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide
CAS No.:184229-67-2
Molecular Formula:C₃₉H₃₇N₅O₆
Molecular Weight:671.753
Hs Code.:

Synonyms:N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

There total 10 articles about N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 184229-66-1
N-{9-[(2R,4S,5R)-4-Hydroxy-5-(2-hydroxy-ethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 184229-67-2
N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With pyridine; at 0 ℃; for 1h;
DOI:10.1021/ja961788h

Reference yield:

: 14686-89-6
(1,2:5,6)-di-O-isopropylidene-D-gulose

: 184229-67-2
N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 10 steps

1: sodium hydride / dimethylformamide / 1 h / Ambient temperature

2: acetic acid, p-toluenesulfonic acid monohydrate / 1 h / Heating

3: 71 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 12 h / 55 °C

4: 86 percent / ethanolic NaOH / pyridine / 0.17 h / Ambient temperature

5: 97 percent / imidazole / CH₂Cl₂ / 1 h / Ambient temperature

6: 90 percent / tetrahydrofuran / 12 h / 65 °C

7: 80 percent / Bu₃SnH, azobisisobutyronitrile / toluene / 1.5 h / 75 °C

8: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Ambient temperature

9: 83 percent / H₂ / Pd black / ethanol / 9 h / 45 °C / 760 Torr

10: 81 percent / pyridine / 1 h / 0 °C

With pyridine; 1H-imidazole; sodium hydroxide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; sodium hydride; toluene-4-sulfonic acid; acetic acid; palladium; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja961788h

Reference yield:

: 22331-21-1
1,2:5,6-di-O-isopropylidene-3-O-benzyl-α-D-allofuranose

: 184229-67-2
N-[9-((2R,4S,5R)-5-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid, p-toluenesulfonic acid monohydrate / 1 h / Heating

2: 71 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 12 h / 55 °C

3: 86 percent / ethanolic NaOH / pyridine / 0.17 h / Ambient temperature

4: 97 percent / imidazole / CH₂Cl₂ / 1 h / Ambient temperature

5: 90 percent / tetrahydrofuran / 12 h / 65 °C

6: 80 percent / Bu₃SnH, azobisisobutyronitrile / toluene / 1.5 h / 75 °C

7: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 5 h / Ambient temperature

8: 83 percent / H₂ / Pd black / ethanol / 9 h / 45 °C / 760 Torr

9: 81 percent / pyridine / 1 h / 0 °C

With pyridine; 1H-imidazole; sodium hydroxide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; acetic acid; palladium; In tetrahydrofuran; pyridine; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ja961788h