(2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

Base Information

Chemical Name:(2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole
CAS No.:88154-81-8
Molecular Formula:C₂₁H₃₁NO
Molecular Weight:313.483
Hs Code.:

Synonyms:(2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

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Chemical Property of (2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

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Technology Process of (2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

There total 6 articles about (2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 622-30-0
N-benzyl hydroxylalmine

: 88057-69-6
3-((1R,4S,5R)-4-Butyl-5-methyl-cyclohex-2-enyl)-propionaldehyde

: 88154-81-8
(2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

Guidance literature:: In benzene; at 80 ℃; for 8h;
DOI:10.1021/ja00315a044

Reference yield:

: 86509-55-9,86509-56-0,88154-78-3,88154-79-4
(R)-6-Butyl-5-methyl-cyclohex-2-enone

: 88154-81-8
(2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1: TiCl₄ / CH₂Cl₂ / 1.5 h / -78 °C

2: 1.) LDA, HMPT / 1.) THF, -78 deg C, 1.5h, 0 deg C, 20min; 2.) 23 deg C, 4h, THF

3: 9-BBN / tetrahydrofuran / 4 h / 0 °C

4: 95 percent / Li, EtNH₂, t-BuOH / tetrahydrofuran

5: 90 percent / PCC / CH₂Cl₂ / 23 °C

6: 80 percent / benzene / 8 h / 80 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 9-borabicyclo[3.3.1]nonane dimer; titanium tetrachloride; lithium; ethylamine; pyridinium chlorochromate; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ja00315a044

Reference yield:

: 88057-67-4
3-((1R,4S,5R)-4-Butyl-5-methyl-cyclohex-2-enyl)-propan-1-ol

: 88154-81-8
(2aR,4aR,6R,7S,7aS,7bS)-2-Benzyl-7-butyl-6-methyl-decahydro-indeno[1,7-cd]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / PCC / CH₂Cl₂ / 23 °C

2: 80 percent / benzene / 8 h / 80 °C

With pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1021/ja00315a044