2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

Base Information

Chemical Name:2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine
CAS No.:476171-57-0
Molecular Formula:C₂₉H₃₅NO₄
Molecular Weight:461.601
Hs Code.:

Synonyms:2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

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Chemical Property of 2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

Chemical Property:

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Technology Process of 2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

There total 7 articles about 2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

: 476171-56-9
2R-(1'R-phenylmethoxy-4'-[(4-methoxyphenyl)methoxy]butyl)-N-tert-butyloxycarbonyl-3R,4S-diphenylmethoxypyrrolidine

: 476171-57-0
2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1021/jo025977w

Reference yield:

: 476171-68-3
6-[(4-methoxyphenyl)methoxy]-(2R,3R)-epoxyhexan-1-al

: 476171-57-0
2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: KHMDS / toluene / 0.08 h / 0 °C

1.2: 2.76 g / toluene / 3 h / 0 - 20 °C

2.1: 88.2 percent / p-toluenesulfonic acid monohydrate / 72 h / 105 °C

3.1: 98 percent / triethylamine / tetrahydrofuran / 24 h / 20 °C

4.1: 95.2 percent / benzylidene-bis(tricyclohexylphosphine)dichlororuthenium / CH₂Cl₂ / 20 h / Heating

5.1: 89.5 percent / K₂OsO₄*2H₂O; N-methylmorpholine N-oxide; water / acetone / 24 h / 20 °C

6.1: 90.3 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 h / 20 °C

7.1: 89.4 percent / trifluoroacetic acid; anisole / CH₂Cl₂ / 2.5 h / 20 °C

With potassium osmate(VI); Grubbs catalyst first generation; water; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; toluene-4-sulfonic acid; methoxybenzene; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone; toluene;
DOI:10.1021/jo025977w

Reference yield:

: 476171-46-7
7-[(4-methoxyphenyl)methoxy]-(3R,4R)-epoxy-1-heptene

: 476171-57-0
2R-(1'R-phenylmethoxy-4'-hydroxy)butyl-3R,4S-diphenylmethoxypyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 88.2 percent / p-toluenesulfonic acid monohydrate / 72 h / 105 °C

2: 98 percent / triethylamine / tetrahydrofuran / 24 h / 20 °C

3: 95.2 percent / benzylidene-bis(tricyclohexylphosphine)dichlororuthenium / CH₂Cl₂ / 20 h / Heating

4: 89.5 percent / K₂OsO₄*2H₂O; N-methylmorpholine N-oxide; water / acetone / 24 h / 20 °C

5: 90.3 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 h / 20 °C

6: 89.4 percent / trifluoroacetic acid; anisole / CH₂Cl₂ / 2.5 h / 20 °C

With potassium osmate(VI); Grubbs catalyst first generation; water; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; methoxybenzene; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo025977w