Technology Process of (20S)-2-methylene-22-(imidazol-1-yl)-19,23,24,25,26,27-esanor-1α-hydroxyvitamin D3
There total 5 articles about (20S)-2-methylene-22-(imidazol-1-yl)-19,23,24,25,26,27-esanor-1α-hydroxyvitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine; tetrapropylammonium perruthennate / dichloromethane / 1 h / 20 °C / Molecular sieve
2.1: phenyllithium / tetrahydrofuran; dibutyl ether / -78 - -20 °C / Inert atmosphere
2.2: 21 h / -78 - 0 °C / Inert atmosphere
3.1: hydrogen fluoride / water; acetonitrile / 8 h / 0 - 20 °C
With
4-methyl-morpholine; tetrapropylammonium perruthennate; hydrogen fluoride; phenyllithium;
In
tetrahydrofuran; dichloromethane; dibutyl ether; water; acetonitrile;
2.1: Horner-Wittig reaction / 2.2: Horner-Wittig reaction;
DOI:10.1016/j.steroids.2011.11.007
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; dibutyl ether / -78 - -20 °C / Inert atmosphere
1.2: 21 h / -78 - 0 °C / Inert atmosphere
2.1: hydrogen fluoride / water; acetonitrile / 8 h / 0 - 20 °C
With
hydrogen fluoride; phenyllithium;
In
tetrahydrofuran; dibutyl ether; water; acetonitrile;
1.1: Horner-Wittig reaction / 1.2: Horner-Wittig reaction;
DOI:10.1016/j.steroids.2011.11.007
