<1R,(4R)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

Base Information

Chemical Name:<1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate
CAS No.:87766-75-4
Molecular Formula:C₂₀H₂₈BrNO₄
Molecular Weight:426.351
Hs Code.:

Synonyms:<1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

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Chemical Property of <1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

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Technology Process of <1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

There total 3 articles about <1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 108-24-7
acetic anhydride

: 87766-73-2
(1R*,5R*,6R*)-6-(3-Bromopropyl)-5-(2,3-dimethoxyphenyl)-2-methyl-7-oxa-2-azabicyclo<3.2.1>octane

: 87766-75-4
<1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

Guidance literature:: In trifluoroacetic acid; for 1h; Ambient temperature;
DOI:10.1021/jo00190a019

Reference yield:

: 82359-63-5
4-(2,3-Dimethoxyphenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine

: 87766-75-4
<1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

Guidance literature:: Multi-step reaction with 3 steps

2: triphenylphosphine, Br₂ / tetrahydrofuran / 0.25 h

3: 59 percent / trifluoroacetic acid / 1 h / Ambient temperature

With bromine; triphenylphosphine; In tetrahydrofuran; trifluoroacetic acid;
DOI:10.1021/jo00190a019

Reference yield:

: 87766-68-5
(1R*,5R*,6R*)-5-(2,3-Dimethoxyphenyl)-2-methyl-6-(3-hydroxypropyl)-7-oxa-2-azabicyclo<3.2.1>octane

: 87766-75-4
<1R*,(4R*)>-4-Bromo-1-(4-<2,3-dimethoxyphenyl>-1,2,3,4-tetrahydro-1-methylpyrid-4-yl)-1-butanol Acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine, Br₂ / tetrahydrofuran / 0.25 h

2: 59 percent / trifluoroacetic acid / 1 h / Ambient temperature

With bromine; triphenylphosphine; In tetrahydrofuran; trifluoroacetic acid;
DOI:10.1021/jo00190a019