N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester

Base Information

• Chemical Name: N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester
• CAS No.: 1430197-59-3
• Molecular Formula: C₄₈H₆₂N₂O₉Si
• Molecular Weight: 839.114

Synonyms:N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester

Chemical Property of N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester

There total 3 articles about N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(N-phenyl)-2,2,2-trifluoroacetimido-5-triisopropylsilyl-2,3-O-benzyl-α,β-D-ribofuranose + benzyl 5-amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoate (95700-16-6) → Nδ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-Nα-benzyloxycarbonylglutamine benzyl ester (1430197-59-3)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -20 - 20 ℃; stereoselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ol400929c

Reference yield:

5-triisopropylsilyl-2,3-O-benzyl-D-ribose → Nδ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-Nα-benzyloxycarbonylglutamine benzyl ester (1430197-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetone; water / 16 h / 20 °C

2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / -20 - 20 °C / Molecular sieve; Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; caesium carbonate; In dichloromethane; water; acetone;

DOI:10.1021/ol400929c

Reference yield:

allyl 5-triisopropylsilyl-2,3-bis-O-benzyl-α,β-D-ribofuranoside → Nδ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-Nα-benzyloxycarbonylglutamine benzyl ester (1430197-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate; hydrogen / tetrahydrofuran / 1 h / 20 °C / Molecular sieve; Inert atmosphere

2: caesium carbonate / acetone; water / 16 h / 20 °C

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / -20 - 20 °C / Molecular sieve; Inert atmosphere

With (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate; trimethylsilyl trifluoromethanesulfonate; hydrogen; caesium carbonate; In tetrahydrofuran; dichloromethane; water; acetone;

DOI:10.1021/ol400929c

upstream raw materials:

benzyl 5-amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1430197-59-3 N^δ-(5-triisopropylsilyl-2,3-di-O-benzyl-α-D-ribosyl)-N^α-benzyloxycarbonylglutamine benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send