(R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride

Base Information

• Chemical Name: (R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride
• CAS No.: 99198-05-7
• Molecular Formula: C₂₂H₃₀N₂O₇*ClH
• Molecular Weight: 470.95
• Mol file: 99198-05-7.mol

Synonyms:(R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride

Chemical Property of (R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride

There total 1 articles about (R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde (50675-18-8) → (R)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester; hydrochloride (99198-05-7)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene / 1 h / Heating

2: H₂ / 10 percent Pd-C / ethanol / Ambient temperature

3: 1) NaOEt; 2) H₂SO₄, LiCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

4: 26 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

5: 72 percent / H₂, HCl / 10 percent Pd-C / ethanol / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; lithium chloride; palladium on activated charcoal; In ethanol; acetic acid; benzene;

DOI:10.1248/cpb.34.1128

upstream raw materials:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

Refernces